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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK2
All Species:
19.39
Human Site:
S261
Identified Species:
26.67
UniProt:
P24941
Number Species:
16
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24941
NP_001789.2
298
33930
S261
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Chimpanzee
Pan troglodytes
XP_523720
325
36841
D281
N
L
E
P
E
G
R
D
L
L
M
Q
L
L
Q
Rhesus Macaque
Macaca mulatta
XP_001113345
298
33812
S261
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Dog
Lupus familis
XP_856049
298
33839
S261
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Cat
Felis silvestris
Mouse
Mus musculus
P97377
346
38960
S309
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Rat
Rattus norvegicus
Q63699
298
33869
S261
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P13863
303
34670
D262
N
L
D
E
D
G
L
D
L
L
S
K
M
L
I
Frog
Xenopus laevis
P23437
297
33852
D261
P
L
D
E
D
G
R
D
L
L
A
Q
M
L
Q
Zebra Danio
Brachydanio rerio
NP_998571
298
34001
D261
P
L
D
E
D
G
R
D
L
L
G
Q
M
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23573
314
35870
I264
E
H
E
A
H
E
L
I
M
S
M
L
C
Y
D
Honey Bee
Apis mellifera
XP_393450
299
34033
D260
S
F
D
S
D
A
K
D
L
L
L
K
L
L
T
Nematode Worm
Caenorhab. elegans
P34556
332
38277
L280
D
K
K
T
G
K
H
L
L
D
D
T
A
F
S
Sea Urchin
Strong. purpuratus
XP_790847
299
34142
D261
M
L
N
K
D
G
K
D
L
L
K
S
M
L
C
Poplar Tree
Populus trichocarpa
XP_002306004
294
33768
T255
D
L
A
T
V
V
P
T
L
E
K
A
G
V
D
Maize
Zea mays
P23111
294
33816
N255
D
L
A
T
V
V
P
N
L
D
P
A
G
L
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
N255
D
L
E
T
F
V
P
N
L
D
P
D
G
V
D
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
P262
K
D
L
S
Q
V
V
P
S
L
D
P
R
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.8
99.6
98.9
N.A.
85.2
98.6
N.A.
N.A.
65.3
88.9
90.2
N.A.
62.7
69.9
56.9
75.9
Protein Similarity:
100
79.6
99.6
99.6
N.A.
85.8
99.6
N.A.
N.A.
77.8
94.9
94.9
N.A.
74.8
82.2
69.8
88.6
P-Site Identity:
100
46.6
100
100
N.A.
100
100
N.A.
N.A.
66.6
80
80
N.A.
0
33.3
6.6
46.6
P-Site Similarity:
100
66.6
100
100
N.A.
100
100
N.A.
N.A.
73.3
86.6
80
N.A.
13.3
53.3
6.6
66.6
Percent
Protein Identity:
66.4
66.7
N.A.
67.1
62.4
N.A.
Protein Similarity:
83.2
82.2
N.A.
81.5
79.1
N.A.
P-Site Identity:
13.3
20
N.A.
13.3
6.6
N.A.
P-Site Similarity:
26.6
26.6
N.A.
33.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
6
0
6
0
0
0
0
6
12
6
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
6
% C
% Asp:
24
6
53
0
59
0
0
36
0
18
12
6
0
0
24
% D
% Glu:
6
0
18
48
6
6
0
0
0
6
0
0
0
0
0
% E
% Phe:
0
6
0
0
6
0
0
0
0
0
0
0
0
6
0
% F
% Gly:
0
0
0
0
6
59
0
0
0
0
6
0
18
6
0
% G
% His:
0
6
0
0
6
0
6
0
0
0
0
0
0
0
30
% H
% Ile:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
12
% I
% Lys:
6
6
6
6
0
6
12
0
0
0
12
12
0
0
0
% K
% Leu:
0
77
6
0
0
0
12
6
89
71
6
6
12
71
0
% L
% Met:
6
0
0
0
0
0
0
0
6
0
12
0
53
0
0
% M
% Asn:
12
0
6
0
0
0
0
12
0
0
0
0
0
0
0
% N
% Pro:
42
0
0
6
0
0
18
6
0
0
12
6
0
0
0
% P
% Gln:
0
0
0
0
6
0
0
0
0
0
0
48
0
0
12
% Q
% Arg:
0
0
0
0
0
0
48
0
0
0
0
0
6
0
0
% R
% Ser:
6
0
0
12
0
0
0
30
6
6
36
6
0
0
6
% S
% Thr:
0
0
0
24
0
0
0
6
0
0
0
6
0
0
12
% T
% Val:
0
0
0
0
12
24
6
0
0
0
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _